![]() ![]() Smoking and age at hire were also significant predictors of lung cancer mortality. Of the models assessed, the linear Cox model with unlagged cumulative exposure provided the best fit and was preferred. Lung cancer was significantly increased for the cohort (standardized mortality ratio (SMR)=186 95% confidence interval (CI) 145-228), for those hired before 1959, those with >30-year tenure, and those with cumulative exposure >1.41 mg/m(3)-years or highest monthly exposures >0.26 mg/m(3). The average length of follow-up was 34.4 years with 24,535 person-years at risk. We updated the mortality of 714 Painesville workers (including 198 short-term workers) through December 2011, reconstructed exposures, and conducted exposure-response modeling using Poisson and Cox regressions to provide quantitative lung cancer risk estimates. ![]() The exposure-response for hexavalent chromium (Cr(VI))-induced lung cancer among workers of the Painesville Ohio chromate production facility has been used internationally for quantitative risk assessment of environmental and occupational exposures to airborne Cr(VI). ![]()
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